产品编号：A104985
产品规格：2mg
产品价格：面议
| 标准品编号: | A104985 |
| 名称: | Abacavir 5’-β-D-Glucuronide Sodium Salt |
| 别名: | [(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl-β-D-Glucopyranosiduronic Acid Sodium Salt; Abacavir 5’-Glucuronide Sodium Salt |
| 备用CAS: | 384329-76-4 free acid |
| 分子式: | C₂₀H₂₅N₆NaO₇ |
| 状态： | Pale Beige Solid |
| 熔点： | >206°C (dec.) |
| 分子量: | 484.44 |
| 储存： | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解性: | Methanol (Slightly), Water (Slightly) |
| 稳定性: | Hygroscopic |
| 类别: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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