产品编号：A100800
产品规格：2.5mg
产品价格：面议
| 标准品编号: | A100800 |
| 名称: | VIP(LA)1155463 Hydrochloride |
| 别名: | 2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic Acid Hydrochloride; |
| 备用CAS: | Free Base: 1235034-55-5 |
| 分子式: | C₃₅H₃₂FN₅O₄S₂•HCl |
| 状态： | Beige Solid |
| 熔点： | >140°C (dec.) |
| 分子量: | 669.793646 |
| 储存： | -20°C Freezer, Under inert atmosphere |
| 溶解性: | Chloroform (Slightly, Heated), DMSO (Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | VIP(LA)1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. VIP(LA)1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (<10 pM), highly selective against closely related proteins of BCL-2 (Ki = 74nM, >7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). VIP(LA)1155463, together with VIP(LA)1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, VIP(LA)1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, kil |
| 危险品信息: | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
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