Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
ONO 5334 is a novel cathepsin K inhibitor. Inhibited bone resorption in human osteoclast and reduced calcium level increased by PTHrP in thyroparathyroidectomized rat and decreased serum and urine C-telopeptide of type I collagen level in monkey. Values in postmenopausal patient with osteoporosis, increases lumbar spine, total hip and femoral neck bone minerals.
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