LSN 2463359 is used as a positive and potent allosteric modulator of the mGlu5 receptor (1,2). LSN 2463359 is highly selective for mGlu5 and exhibits little to no activity for mGlu1-4, mGlu8 and GABAB receptors. Studies showed that LSN 2463359 promotes wakefulness in vivo and cognitive activity. LSN 2463359 also Improve memory and learning characteristics in mice.
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