2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one; 1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one; Methylphenylpyrazolone; NCI-C 03952; NSC 12;NSC 26139; NSC 2629; Norantipyrine; Norphenazone; Radicut; USP Antipyrine Related Compound A
杂质:
Phenazone EP Impurity A
CAS号:
89-25-8
分子式:
C₁₀H₁₀N₂O
外观:
白色至白色固体
熔点:
123-127°C
分子量:
174.2
储存:
-20˚C Freezer
溶解度:
DMSO (Slightly), Methanol (Slightly)
种类:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Edaravone inhibits the disease activity in rheumatoid arthritis. Edaravone can significantly enhance IR flap viability and protect flap vessels, which is related to scavenging oxygen free radicals, reducing the consumption of SOD, reducing the extent of lipid peroxidation and inflammation, and protecting functional structure of vessels in the early stages of reperfusion. It also shows protective effects against STZ-induced cognitive impairment, oxidative stress, cholinergic dysfunction and altered protein expressions. Its acts like a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogenesis through inhibiting JNK and p38 MAPK pathways in AMD, glaucoma, DR, and RVO animal models.
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